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Nuevos Tratamientos con Apitoxina

Veneno de la abeja muestra propiedades anti-cáncer



Bee Venom Suppresses PMA-Mediated MMP-9 Gene Activation via JNK/p38 and NF-κB- Dependent Mechanisms
Journal of Ethnopharmacology, Article in Press, Accepted Manuscript

Bee venom has been used for the treatment of inflammatory diseases such as rheumatoid arthritis and for the relief of pain in traditional oriental medicine.

Aim of the study: The purpose of this study is to elucidate the effects of bee venom on MMP-9 expression and determine possible mechanisms by which bee venom relieves or prevents the expression of MMP-9 during invasion and metastasis of breast cancer cells. We examined the expression and activity of MMP-9 and possible signaling pathway affected in PMA-induced MCF-7 cells.

Material and methods: Bee venom was obtained from the National Institute of Agricultural Science and Technology of Korea. Matrigel invasion assay, wound healing assay, zymography assay, western blot assay, electrophoretic mobility shift assay and luciferase gene assay were used for assessment.

Results: Bee venom inhibited cell invasion and migration, and also suppressed MMP-9 activity and expression, processes related to tumor invasion and metastasis, in PMA-induced MCF-7 cells. Bee venom specifically suppressed the phosphorylation of p38/JNK and at the same time, suppressed the protein expression, DNA binding and promoter activity of NF-κB. The levels of phosphorylated ERK1/2 and c-Jun did not change. We also investigated MMP-9 inhibition by melittin, apamin and PLA2, representative single component of bee venom. We confirmed that PMA-induced MMP-9 activity was significantly decreased by melittin, but not by apamin and phospholipase A2. These data demonstrated that the expression of MMP-9 was abolished by melittin, the main component of bee venom.

Conclusion: Bee venom inhibits PMA-induced MMP-9 expression and activity by inhibition of NF-κB via p38 MAPK and JNK signaling pathways in MCF-7 cells. These results indicate that bee venom can be a potential anti-metastatic and anti-invasive agent. This useful effect may lead to future clinical research on the anticancer properties of bee venom.

El Veneno de Abejas como alternativa a la Toxina Botulínica

It seems that people are willing to go to any length nowadays to look younger and like their favourite celebrities. With more people than ever heading under the knife, we have seeked out the latest alternatives to plastic surgery.

Here at FemaleFirst we think that no-one should be fooled by the glamorised and celebrity endorsed culture of cosmetic surgery. Plastic surgery is full of risks and even the simplest of procedures can go wrong. So, avoid the pain and price in the pursuit of a A-list body, with our tried and tested alternatives…

… we have an all-natural alternative to botox with the Bee Venom Mask by Heaven Skincare. The mask contains bee venom and manuka honey which gently firms, smoothes and plumps the skin. At just £55 it is a lot cheaper than a series of botox injections.

The mask uses only natural and organic ingredients, which are combined to work in synergy for an instant anti-ageing effect. Manuka Honey in the mask is renowned for its soothing and healing properties, it also contains Bee Venom which works to control the facial muscles for immediate lifting, tightening and firming. Just apply the mask daily and leave on for 20 minutes before washing off to get instant younger and smoother skin to rival Madonna.
 

Apiterapia, la solución natural. Para la artrosis. La inflamación y el dolor.
La apitoxina (veneno de abejas). Su mejor opción.
80% de resultados positivos, rápido, seguro, eficaz.
Dr. Eduardo A. Katsiyannis
15 años de experiencia con 60.000 pacientes atendidos
GARANTÍA DE EXCELENCIA

Capital Federal: Av. Córdoba 1335 Piso 7 dpto. "A"
Turnos al Tel:
(011)4856-7251 - (011)15-3326-8345

Buenos Aires, Argentina